Education

(Aug. 2010 - Dec. 2014); Doctor of Philosophy, Genetics and Aquaculture Breeding, School of Fisheries, Auburn University, Auburn, Alabama.

(Sept. 2006 - June. 2010); Bachelor of Science, Marine Biology, College of Marine Life, Ocean University of China, Qingdao, Shandong, China

Career history 

(Nov. 2014 - 2021); PostDoc Associate, Huffington Center on Aging, Baylor College of Medicine, Houston, Texas, US

(2021 - present); Associate Professor, Single-Cell Center, QIBEBT, CAS, China

Skills

• Programming: Linux, SAS, R, Perl, Python

• High-Throughput Sequencing data analysis: RNA-Seq, ChIP-Seq, ATAC-seq, WGBS, et al.

• Hi-C and chromatin 3D conformational analysis

• Single-cell sequencing

• Genomic variation identification

• GWAS

• Genome assembly and annotation

• Molecular experimental skills

• Fish culture, dissection and disease challenge

• Cell Culture

    

Featured Publication

(2021) McCauley BS#, Sun L#, Yu R, Leeman D, Huang Y, Webb AE, and Dang W. Age-associated cryptic transcription in mammalian stem cells is linked to permissive chromatin at cryptic promoters. Nature Aging, 2020. (# indicates equal contribution, 2nd term review)

(2020) Sun, L. and Dang, W., 2020. SIRT7 slows down stem cell aging by preserving heterochromatin: a perspective on the new discovery. Protein & Cell.

(2019) Sun, L., McCauley, B., & Dang, W. YY1-mediated promoter-super enhancer interactions regulate MSC multipotency during replicative aging. Innovation in Aging, 3(Suppl 1), S912. DOI: 10.1093/geroni/igz038.3328

(2018) Sun, L., Yu, R., Dang W., Chromatin Architectural Changes during Cellular Senescence and Aging. Genes (Basel), 2018 Apr 16;9(4)

(2015) Sun, L., Liu, S., Bao, L., Li, Y., Feng, J., & Liu, Z. Claudin multigene family in channel catfish and their expression profiles in response to bacterial infection and hypoxia as revealed by meta-analysis of RNA-Seq datasets. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 13, 60-69.

(2014) L. Sun, S. Liu, R. Wang, Y. Jiang, Y. Zhang, J. Zhang, L. Bao, L. Kaltenboeck, R. Dunham, G. Waldbieser, Z. Liu. Identification and analysis of genome-wide SNPs provide insight into signatures of selection and domestication in catfish. PloS one, 9.10 (2014): e109666.

(2014) L. Sun, S. Liu, R. Wang, C. Li, J. Zhang, Z. Liu. Pathogen recognition receptors in channel catfish: IV. Identification, phylogeny and expression analysis of peptidoglycan recognition proteins. Developmental & Comparative Immunology, 2014 http://dx.doi.org/10.1016/j.dci.2014.04.018.

(2014) R. Wang, L. Sun, L. Bao, J. Zhang, Y. Jiang, J. Yao, L. Song, J. Feng, S. Liu, Z. Liu. Bulk segregant RNA-seq reveals expression and positional candidate genes and allele-specific expression for disease resistance against enteric septicemia of catfish. BMC genomics, 2013, 14(1): 929. (Co-first author)