​Raman spectroscopy is a scattering technique that relies on the inelastic scattering of photons. The excitation of molecular bonds results in the shifts of the energy of laser photons and thus frequency change of the incident light. Therefore, a compound can have a specific Raman spectrum, while a Single-cell Raman Spectrum (SCRS) can depict the overall profile of metabolites in the cell, i.e...

Researchers from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences (CAS) andHainan University havedeveloped a workflow for detecting metabolites in single cells of corals in situ. This new platform sheds light on the transfer and recycling of carbon and nitrogen across the coral-Symbiodiniaceae-bacteria consortium. It also produces the firs...

Scientists from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences (CAS) and the Tianjin Institute of Industrial Biotechnology (TIB) of CAS, have developed a rapid, high-throughput error-correction platform that significantly improves the accuracy of synthetic DNA. The system, known as engineered MutS-based magnetic bead separation (eMBS), o...

Scientists from Jiangnan University and the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of Chinese Academy of Sciences have uncovered new insights into the microbial dynamics of high-temperatureDaqufermentation.Published on December 16 in Bioresource Technology, the study reveals how yeast species collaborate to maintain metabolic activity under extreme fermentation condit...

​Scientists from the Qingdao Institute of Bioenergy and Bioprocess Technology of the Chinese Academy of Sciences (CAS) have developed a novel computational tool, RamEx, designed to resolve the computational bottleneck in high-throughput microbial Ramanomics. The findings were recently published in Microbiome.RamEX: a modularized pipeline for ramanome analysis（Image by LIU Yang)The study is ex...

​Breweries typically monitor fermentation by analyzing broth composition. Alcohols, esters, acids and residual sugars are quantified via chromatography-based assays. While reliable, these tests are time-consuming and only yield batch-average results.Now, a new study demonstrates that rapid, label-free readings from individual yeast cells can be translated into many of these same key process me...

A research team from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences, has developed a fully automated "Digital Colony Picker" (DCP). This device identifies and retrieves high-performance microbial clones by simultaneously monitoring their growth and metabolite production—eliminating the need for culture plates, sampling needles, or manua...

​Marine microalgae are vital drivers of Earth's carbon cycle, contributing approximately half of the planet's global primary production and sequestering tens of gigatons of carbon annually through photosynthesis. To survive and thrive in seawater with low carbon dioxide (CO2) levels, these microorganisms depend on specialized and efficient CO2-concentrating mechanisms (CCMs). For years, the re...

Chinese researchers have developed a new platform that cuts the time to diagnose bloodstream bacterial infections and identify effective antibiotics from days to just 12 hours, according to a recent study published in Sensors and Actuators B: Chemical.A microfluidic chip-based platform enables rapid detection of pathogens. (Image by LIU Yang)A research team from the Qingdao Institute of Bioener...

​Researchers from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences, in collaboration with Qingdao University of Science and Technology and Zhangcun River Purification Plant, have developed a high-resolution strategy to identify and utilize naturally occurring phosphorus-removing microbes. Their findings were published in the journal Water...