​Raman spectroscopy is a scattering technique that relies on the inelastic scattering of photons. The excitation of molecular bonds results in the shifts of the energy of laser photons and thus frequency change of the incident light. Therefore, a compound can have a specific Raman spectrum, while a Single-cell Raman Spectrum (SCRS) can depict the overall profile of metabolites in the cell, i.e...

A research team from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences, has developed a fully automated "Digital Colony Picker" (DCP). This device identifies and retrieves high-performance microbial clones by simultaneously monitoring their growth and metabolite production—eliminating the need for culture plates, sampling needles, or manua...

​Marine microalgae are vital drivers of Earth's carbon cycle, contributing approximately half of the planet's global primary production and sequestering tens of gigatons of carbon annually through photosynthesis. To survive and thrive in seawater with low carbon dioxide (CO2) levels, these microorganisms depend on specialized and efficient CO2-concentrating mechanisms (CCMs). For years, the re...

Chinese researchers have developed a new platform that cuts the time to diagnose bloodstream bacterial infections and identify effective antibiotics from days to just 12 hours, according to a recent study published in Sensors and Actuators B: Chemical.A microfluidic chip-based platform enables rapid detection of pathogens. (Image by LIU Yang)A research team from the Qingdao Institute of Bioener...

​Researchers from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences, in collaboration with Qingdao University of Science and Technology and Zhangcun River Purification Plant, have developed a high-resolution strategy to identify and utilize naturally occurring phosphorus-removing microbes. Their findings were published in the journal Water...

​A collaborative research team led by the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences has uncovered the antibacterial mechanisms of cationic and anionic surfactants against Staphylococcus aureus using single-cell Raman spectroscopy (SCRS) in a multi-dimensional approach.Published in Analytical Chemistry, this study provides insights into...

​Researchers from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences, in collaboration with their partners, have developed a novel method for the comprehensive evaluation of probiotic products using a Raman Flow Cytometry (RFC) platform.Published in iMetaOmics, this new method allows for rapid, label-free analysis of identity, viability, an...

​Chinese researchers have developed an advanced, high-throughput single-cell sorting platform that enables direct isolation of living cells with targeted metabolic profiles from large mutant libraries.The technology—now commercialized as FlowRACS 3.0—dramatically shortens the traditionally labor-intensive, colony-by-colony screening process for identifying high-value microbial strains. What ...

Researchers from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) and the Institute of Oceanology, both under the Chinese Academy of Sciences, have discovered new insights into how marine organisms adapt to extreme deep-sea environments.Their study, published in Communications Biology, investigates the transcriptional and metagenomic changes in shallow-water mussels (Mytilu...

​A cutting-edge technology developed by Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT), Chinese Academy of Sciences, in collaboration with several renowned institutions, is poised to transform the discovery of microbial species and enzymes with specific in situ metabolic functions.The team’s findings were published in The Innovation on Jan 17.Phylogeny-metabolism dual-direc...