​Raman spectroscopy is a scattering technique that relies on the inelastic scattering of photons. The excitation of molecular bonds results in the shifts of the energy of laser photons and thus frequency change of the incident light. Therefore, a compound can have a specific Raman spectrum, while a Single-cell Raman Spectrum (SCRS) can depict the overall profile of metabolites in the cell, i.e...

​Researchers from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences, in collaboration with Qingdao University of Science and Technology and Zhangcun River Purification Plant, have developed a high-resolution strategy to identify and utilize naturally occurring phosphorus-removing microbes. Their findings were published in the journal Water...

​A collaborative research team led by the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences has uncovered the antibacterial mechanisms of cationic and anionic surfactants against Staphylococcus aureus using single-cell Raman spectroscopy (SCRS) in a multi-dimensional approach.Published in Analytical Chemistry, this study provides insights into...

​Researchers from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences, in collaboration with their partners, have developed a novel method for the comprehensive evaluation of probiotic products using a Raman Flow Cytometry (RFC) platform.Published in iMetaOmics, this new method allows for rapid, label-free analysis of identity, viability, an...

​Chinese researchers have developed an advanced, high-throughput single-cell sorting platform that enables direct isolation of living cells with targeted metabolic profiles from large mutant libraries.The technology—now commercialized as FlowRACS 3.0—dramatically shortens the traditionally labor-intensive, colony-by-colony screening process for identifying high-value microbial strains. What ...

Researchers from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) and the Institute of Oceanology, both under the Chinese Academy of Sciences, have discovered new insights into how marine organisms adapt to extreme deep-sea environments.Their study, published in Communications Biology, investigates the transcriptional and metagenomic changes in shallow-water mussels (Mytilu...

​A cutting-edge technology developed by Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT), Chinese Academy of Sciences, in collaboration with several renowned institutions, is poised to transform the discovery of microbial species and enzymes with specific in situ metabolic functions.The team’s findings were published in The Innovation on Jan 17.Phylogeny-metabolism dual-direc...

​A team of researchers from the Single-Cell Center at the Qingdao Institute of Bioenergy and Bioprocess Technology of the Chinese Academy of Sciences, along with collaborators, have developed a microfluidic system to tackle antimicrobial resistance (AMR). Operating at the picoliter scale, the system condenses billions of bacterial cells into a confined microenvironment, accelerating the experi...

Cancer metastasis, a leading cause of cancer-related deaths, involves a complex, multi-stage process. Traditional methods for assessing metastatic potential are often time-consuming and labor-intensive, with limited accessibility to samples.Researchers from Qingdao University and Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences have developed ...

Researchers from the Single-Cell Center at the Qingdao Institute of Bioenergy and Bioprocess Technology of the Chinese Academy of Sciences, together with collaborators, developed an artificial intelligence-assisted Raman-activated cell sorting (AI-RACS) system. This innovative system automated the isolation and functional analysis of aluminum-tolerant microorganisms (ATMs) from acidic soil, mar...