Research Interests

· Epigenetic regulation of gene expression

· Functional adaptation mechanisms and ecological assessment of marine microalgae and microorganisms

· Integrative analysis of single-cell Raman spectroscopy and sequencing-based omics

· Algorithms and methods for high-throughput Raman spectral data analysis

Selected Publications

1. McCauley, B^#, Sun, L^#, Yu, R., Leeman, D., Huang, Y., Webb, A., & Dang, W. Altered chromatin states drive cryptic transcription in aging mammalian stem cells. Nature Aging, 1.8 (2021): 684-697.

2. Gong Y, Wang Q, …, Sun L*, Xu J*. Multi-dimensional epigenomic dynamics converge on H3K4-mediated regulation of low-CO₂ adaptation in Nannochloropsis oceanica. Plant Communications 6.12 (2025).

3. Zhang Y, Jing G, ..., Xu J*, Sun L*, RamEx: an R package for high‑throughput microbial ramanome analyses with accurate quality assessment. Microbiome. 2026.

4. Sun L^#, Liu X^#, Zhou L^#, …, Li C*. Shallow-water mussels (Mytilus galloprovincialis) adapt to deep-sea environment through transcriptomic and metagenomic insights. Communications Biology 8.1 (2025): 46.

5. Xu T, Dai Y, Ge A, …, Liu J*, Sun L*, Xu J*, Ma B*. Ultrafast Evolution of Bacterial Antimicrobial Resistance by Picoliter-Scale Centrifugal Microfluidics. Analytical Chemistry 96.47 (2024): 18842-18851.

6. Lü F, Zhang Y, Liang H*, Sun L*. Unsupervised classification of environmental marine microbes using a Raman spectra-based deep learning framework. Journal of Oceanology and Limnology (2025): 1-15.

7. Sun L, Dang W. SIRT7 slows down stem cell aging by preserving heterochromatin: a perspective on the new discovery. Protein & cell 11.7 (2020): 469-471.

8. Liu L, Yan Z, Osia BA, Twarowski J, Sun L, Kramara J, …, Dang W, Ira G, Malkova A. "Tracking break-induced replication shows that it stalls at roadblocks." Nature 590.7847 (2021): 655-659.

Full publication list:

https://scholar.google.jp/citations?hl=en&user=0Ug9WP8AAAAJ&view_op=list_works&sortby=pubdate