Year-2026-Single-Cell Center, QIBEBT, CAS

Engineered eMutS based magnetic separation system for high-fidelity DNA synthesis

Xiaohang Wang#, Yefei Wang#, Wei Wang#, Wenshuang Liu, Hui Jia, Mengsha Li, Mingying Li, Changle Wu, Jian Xu, Xiang Sheng*, Jia Zhang*

Synthetic and Systems Biotechnology13: 337–349

2026 View DOI

Antifungal Susceptibility Test via single-cell morphology, development, and metabolism

Xiao Han, Yanmei Zhang, Xiaoshan Zheng, Xixian Wang, Rongze Chen, Min Liu, Qiwen Yang, Guanghua Huang, Yu Vincent Fu, Bo Ma, Jiadong Huang*, Jian Xu*

Analytical Chemistry98(13): 9697–9714

2026 View DOI

Label-free, single-cell-precision and monomeric-unit-resolved monitoring of biopolymer fermentation by ramanomics

Jia Zhang#, Xu Liu#, Zhihang Chen#, Xuan Zhou, Mingying Li, Zengyan Sun, Teng Xu, Taoran Zheng, Xiaomeng Wang, Xinnan Cui, Jiajun Du, Gongchao Jing, Yanmei Zhang, Mingqin Xu, Bo Ma, Fuli Li, Huiying Luo, Bin Yao, Guo-Qiang Chen*, Jian Xu*

Trends in BiotechnologyOnline ahead of print

2026 View DOI

Rapid and quantitative phage susceptibility test by ramanome

Xiao Han#, Xiaofu Wan#, Yang Zhou, Xiaoting Fu, Xiaoshan Zheng, Bo Gao, Shi Huang, Anle Ge, Jiadong Huang*, Hongzhou Lu*, Jian Xu*

mLife5(3): 369–382

2026 View DOI

From fragmented workflows to integrated pipelines: Bridging enzymatic DNA synthesis, assembly, and MutS-based error correction

Xiaohang Wang, Xinran Zhang, Wenfei Yu, Wenshuang Liu, Jian Xu, Shuangying Jiang*, Xiaoyun Lu*, Jia Zhang*

Biotechnology Advances91: 108941

2026 View DOI

Metabolism-driven and high-efficiency mining of ethanol-tolerant microorganisms from pit mud microbiota using Raman-activated cell sorting

Teng Xu#, Qing Sun#, Gongchao Jing#, Yongming Duan, Xiaohang Wang, Xinyun Yi, Changle Wu, Huizi Zhu, Bo Ma, Jian Xu, Xiaowei Zheng*, Xixian Wang*, Jia Zhang*

Bioresource Technology461: 135397

2026 View DOI

RamEx: an R package for high-throughput microbial ramanome analyses with accurate quality assessment

Yanmei Zhang#, Gongchao Jing#, Rongze Chen, Yanhai Gong, Yuandong Li, Yongshun Wang, Xixian Wang, Jia Zhang, Yuli Mao, Yuehui He, Xiaoshan Zheng, Mingchao Wang, Hao Yuan, Jian Xu*, Luyang Sun*

Microbiome14(1): 89

2026 View DOI

High-throughput Raman-activated cell sorting of microalgal genome-wide edited library revealed a regulatory pathway for carotenoid synthesis

Qintao Wang#, Yanhai Gong#, Lianhong Wang, Nana Lv, Xuefeng Du, Jiashun Zhang, Yi Xin, Zoran Nikoloski, Yonghua Li-Beisson, Luyang Sun, Bo Ma*, Xixian Wang*, Jian Xu*

Nature Communications17(1): 8352

2026 View DOI

Microbiomes for a stable planet: Embedding microbial processes in global climate action

Emma Rocke*, Rob Knight, Guilia Ghisleni, Tim McAllister, Alice Ortmann, Antonia Bruno, Diego J. Jimenez, Jian Xu

Green Carbon4(2): 244–248

2026 View DOI

An integrated platform for high-throughput analysis and sorting of single mammalian cells

Xiuyun Li#, Anle Ge#, Zhidian Diao, Wenjie Zhao, Lingyan Kan, Sijun Luo, Wei Gao, Xixian Wang, Jian Xu*, Bo Ma*

Sensors and Actuators B: Chemical463: 140118

2026 View DOI

Precise probiotic therapy: Advances, bottlenecks, and the road to microbiome-informed nutrition

Yuesong Jiang, Shuaiming Jiang, Zhengting Wang, Pengfei Zhu, Jiachao Zhang, Fei Teng*, Shi Huang*

Gut Microbes18(1): 2623359 第三单位

2026 View DOI

Reconstruction of coral holobionts and elucidation of the causal relationships among symbiodiniaceae, bacteria, and coral through single-cell Raman spectroscopy metabolomics

Yang Shu, Yuehui He, Tianhui Chen, Yuanyuan Zhou, Yawen Liu, Pengcheng Fu*, Jian Xu*

Microbiome14(1): 103 第三单位

2026 View DOI

Rapid classification of Pantoea spp. via Raman Flow Cytometry

Daoshun Zhang, Shuhua Tian, Bing Feng, Fu Yang, Pengfei Zhu, Qianyu Wu, Jian Xu, Haisheng Wang*, Xiaoxia Zhang*

Analytical Chemistry98(10): 7854–7867 第三单位

2026 View DOI

Cross-domain transfer of trehalose biosynthesis genes contributes to adaptation in high-altitude environments

Yaohai Wang, Jiahao Ni, Jiao Pan, Ruobing Feng, Weiyi Li, Xuetao Zhang, Chao Gao, Lijian Liao, Zhirong Zhang, Hongwei Yue, Kexin Zhang, Lin Zhang, Chunhui Feng, Dongji Yao, Yumin Han, Xunrong Li, Xuan Zhou, Ziguang Deng, Jia Zhang, Pin Zhou, Gongchao Jing, Yu Zhang, Lingyun Chen, Xuming Pan, Xiangrui Chen, Yang Bai, Ying Yan, Jie Huang, Zhiqiang Ye, Xiaopeng Shen, Miao Tian, Rebecca A. Zufall, Pingyuan Wang, Michael Lynch, Hongan Long*

National Science Review13(8): nwag117 第五单位

2026 View DOI

Microbial cleavage and mineralization of acesulfame by Shinella sp. strain KJ01

Pengfei Yang, Huaqing Liu*, Jian Xu, Yang Liu, Chongyang Ren, Dongle Cheng, Yanlong Wang, Longlong Zhang, Xiaoqiang Cao, Max M. Häggblom, Jian Zhang*

Water Research306: 126561 第五单位

2026 View DOI

Quorum sensing-driven metabolic altruism of nitrite-oxidizing bacteria fuels nitritation

Xuliang Zhuang*, Xu Wang, Cancan Jiang*, Danhua Wang, Shengjun Xu, Lei Wang, Shanghua Wu, Ye Deng, Guibing Zhu, Aamer Ali Shah, Jian Xu

Nature Water4: 992–1006 第六单位

2026 View DOI

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Year-2026

Publications

Engineered eMutS based magnetic separation system for high-fidelity DNA synthesis

Antifungal Susceptibility Test via single-cell morphology, development, and metabolism

Label-free, single-cell-precision and monomeric-unit-resolved monitoring of biopolymer fermentation by ramanomics

Rapid and quantitative phage susceptibility test by ramanome

From fragmented workflows to integrated pipelines: Bridging enzymatic DNA synthesis, assembly, and MutS-based error correction

Metabolism-driven and high-efficiency mining of ethanol-tolerant microorganisms from pit mud microbiota using Raman-activated cell sorting

RamEx: an R package for high-throughput microbial ramanome analyses with accurate quality assessment

High-throughput Raman-activated cell sorting of microalgal genome-wide edited library revealed a regulatory pathway for carotenoid synthesis

Microbiomes for a stable planet: Embedding microbial processes in global climate action

An integrated platform for high-throughput analysis and sorting of single mammalian cells

Precise probiotic therapy: Advances, bottlenecks, and the road to microbiome-informed nutrition

Reconstruction of coral holobionts and elucidation of the causal relationships among symbiodiniaceae, bacteria, and coral through single-cell Raman spectroscopy metabolomics

Rapid classification of Pantoea spp. via Raman Flow Cytometry

Cross-domain transfer of trehalose biosynthesis genes contributes to adaptation in high-altitude environments

Microbial cleavage and mineralization of acesulfame by Shinella sp. strain KJ01

Quorum sensing-driven metabolic altruism of nitrite-oxidizing bacteria fuels nitritation