2010年于潍坊医学院获得理学学士学位，2015年于华中科技大学获得工学博士学位，同年加入中科院青岛生物能源与过程研究所单细胞中心，致力于基于微流控和单细胞拉曼光谱技术的单细胞分析/分选方法学平台研制及工程化，并用于优势菌种选育和酶活筛选等。目前已在Science Advances、Advanced Science、Biotechnology Advances 等国际学术期刊发表论文20余篇，申请/授权专利6项，主持科技部重点研发计划课题、国家自然科学基金面上项目等10余项。

研究方向

单细胞分析/分选、微流控技术、拉曼分选技术

代表性论文

1. Xixian Wang#, Lihui Ren#, Zhidian Diao#, Yuehui He#, Jiaping Zhang, Min Liu, Yuandong Li, Lijun Sun, Rongze Chen, Yuetong Ji, Jian Xu*, Bo Ma*. Robust spontaneous Raman flow cytometry for single-cell metabolic phenome profiling via pDEP-DLD-RFC. Advanced Science, 2023, 10(16): e2207497. IF=15.1

2. Zhidian Diao#, Xixian Wang#, Jiaping Zhang, Anle Ge, Teng Xu, Lingyan Kan, Yuandong Li, Yuetong Ji, Xiaoyan Jing, Jian Xu*, Bo Ma*. Optical-based microbubble for on-demand droplet release from static droplet array (SDA) for dispensing one droplet into one tube. Biosensors and Bioelectronics, 2023, 15(240): 115639. IF=12.6

3. Xixian Wang#, Yi Xin#, Lihui Ren#, Zheng Sun, Pengfei Zhu, Yuetong Ji, Chunyu Li, Jian Xu*, Bo Ma*. Positive dielectrophoresis-based Raman-activated droplet sorting for culture-free and label-free screening of enzyme function in vivo. Science Advances, 2020, 6(32): eabb3521. IF=13.6

4. Yu Wang#, Xixian Wang#, Anle Ge, Liang Hu, Wei Dua*, Bi-Feng Liu*. A dual-stimulation strategy in a micro-chip for the investigation of mechanical associative learning behavior of C. elegans. Talanta, 2020, 1(215): 120900. IF=6.1

5. Yuehui He#, Xixian Wang#, Bo Ma*, jian Xu*. Ramanome technology platform for label-free screening and sorting of microbial cell factories at single-cell resolution. Biotechnology Advances, 2019, 37(6): 107388. IF=16.0

6. Anle Ge#, Xixian Wang#, Minghai Ge, Liang Hu, Xiaojun Feng, Wei Du*, and Bi-Feng Liu*. Profile analysis of C. elegans rheotaxis behavior using a microfluidic device. Lab on a Chip, 2019, 19(3): 475-483. IF=6.1

7. Xixian Wang#, Anle Ge#, Liang Hu, Xiaojun Feng, Wei Du*, Bi-Feng Liu*. A microfluidic microfilter chip driven by electrotaxis and fluid flow for size-dependent C. elegans sorting with high purity and efficiency. Sensors and Actuators B: Chemical, 2018, 260: 311-319. IF=8.4

8. Xixian Wang#, Anle Ge#, Liang Hu, Xiaojun Feng, Wei Du, Bi-Feng Liu*. A novel on-chip immobilization strategy for imaging analysis of neuronal response to gas cues in C. elegans. Sensors and Actuators B-Chemical, 2017, 244: 1152-1159. IF=8.4

9. Xixian Wang#, Lihui Ren#, Yetian Su, Yuetong Ji, Yaoping Liu, Chunyu Li, Xunrong Li, Yi Zhang, Wei Wang, Qiang Hu, Danxiang Han, Jian Xu*, Bo Ma*. Raman-activated droplet sorting (RADS) for label-free high-throughput screening of microalgal single-cells. Analytical Chemistry, 2017, 89(22): 12569-12577. IF=8.0

10. Xixian Wang#, Rui Hu#, Anle Ge, Liang Hu, Shanshan Wang, Xiaojun Feng, Wei Du*, Bi-Feng Liu*. Highly efficient microfluidic sorting device for synchronizing developmental stages of C. elegans based on deflecting electrotaxis. Lab on a Chip, 2015, 15(11): 2513-2521. IF=6.1

专利

1、马波，刁志钿，王喜先，徐腾，徐健。基于光热效应进行微量液滴操控的微流控芯片及方法，专利号：ZL202120019705.8

2、马波，刁志钿，王喜先，徐健。一种基于介电确定性侧向位移的细胞分选芯片、装置及方法，专利号：ZL202010457651.9

3、马波，徐健，王喜先，任立辉，籍月彤。一种拉曼激活液滴分选系统和方法，专利号：ZL201711014803.2