教育与研究背景
2006/09 – 2010/06，中国海洋大学，生物科学，学士
2010/08 – 2014/12，美国奥本大学，鱼类基因组，博士
2014/12 – 2021/10，美国贝勒医学院，分子遗传，博士后
长期致力于基因组学及表观遗传学领域研究。运用高通量测序技术、单细胞技术和生物信息技术研究关键生物过程所涉及的分子通路及其调控机制。建立了多项创新性测序技术和数据分析算法，包括1）基因转录异常检测技术; 2）细胞寿命高通量扫描系统; 3）群体分组分析测序技术; 和4）SNP种群溯源技术等。运用上述方法和技术，揭示了断裂诱导核酸修复，基因转录异常，染色质结构缺陷等多个关键通路的调控机制，相关研究结果发表在Nature, Nature Aging, Nature Communications, Science Advances等多个杂志期刊。目前共发表SCI论文二十余篇，论文总引用次数过千次。担任Frontiers in Genetics、Marine Biotechnology、Scientific report等多个学术杂志审稿人。
研究方向
表观遗传调控基因表达、生物信息、基因组学、单细胞测序
代表性文章
1. McCauley, B.#, Sun, L.#,Yu, R., Leeman, D., Huang, Y., Webb, A., & Dang, W. (2021). Altered chromatin states drive cryptic transcription in aging mammalian stem cells. Nature Aging, 1.8 (2021): 684-697. # Co-first
2. Liu, L., Yan, Z., Osia, B. A., Twarowski, J., Sun, L., Kramara, J., Lee, R. S., Kumar, S., Elango, R., Li, H., Dang, W., Ira, G., & Malkova, A. (2021). Tracking break-induced replication shows that it stalls at roadblocks. Nature. https://doi.org/10.1038/s41586-020-03172-w
3. Yu, R., Cao, X., Sun, L., Zhu, J., Wasko, B., Liu, W., Crutcher, E., Liu, H., Jo, M., Qin, L., Kaeberlein, M., Han, Z., Dang, W., Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism. Nature Communications. 12.1 (2021): 1-16.
4. Sun, L., & Dang, W. (2020). SIRT7 slows down stem cell aging by preserving heterochromatin: a perspective on the new discovery. Protein & Cell, 11(7). https://doi.org/10.1007/s13238-020-00735-5
5. Yu, R., Sun, L., Sun, Y., Han, X., Qin, L., & Dang, W. Cellular response to moderate chromatin architectural defects promotes longevity. Science Advances, 5.7 (2019): eaav1165.
6. Sun, L., Yu, R., & Dang, W. (2018). Chromatin architectural changes during cellular senescence and aging. Genes. https://doi.org/10.3390/genes9040211
7. Wang, R.#, Sun, L.#,Bao, L.#, Zhang, J., Jiang, Y., Yao, J., Song, L., Feng, J., Liu S., Liu, Z. Bulk segregant RNA-seq reveals expression and positional candidate genes and allele-specific expression for disease resistance against enteric septicemia of catfish. BMC Genomics, 2013, 14(1): 929. # Co-first
8. Sun, L., Liu, S., Wang, R., Li, C., Zhang, J., Liu, Z. Pathogen recognition receptors in channel catfish: IV. Identification, phylogeny and expression analysis of peptidoglycan recognition proteins. Developmental & Comparative Immunology, 46.2 (2014): 291-299
9. Sun, L.,Liu, S., Bao, L., Li, Y., Feng, J., & Liu, Z. Claudin multigene family in channel catfish and their expression profiles in response to bacterial infection and hypoxia as revealed by meta-analysis of RNA-Seq datasets. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 13 (2015), 60-69.
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